| Name | Vitamin B2 |
| Synonyms | Vitamin B2 |
| Molecular Formula | C17H20N4O6 |
| Molar Mass | 376.3639 |
| Physical and Chemical Properties | Chemical properties yellow to orange-yellow crystalline powder, slightly smelly, slightly bitter taste. Melting point 280 ℃ (decomposition). Soluble in alkaline solution and sodium chloride solution, slightly soluble in water, slightly soluble in ethanol, insoluble in ether and chloroform. The aqueous solution is yellow-green, and the saturated aqueous solution is neutral. Heat resistance, acid resistance is better, in alkaline solution or by ultraviolet radiation is vulnerable to damage, reducing agent is not stable, rats intraperitoneal injection of LD50560mg/kg. |
| Use | Uses Vitamin B2 is a feed Nutrition Fortifier. Lack of livestock and poultry, will reduce the utilization rate of feed, endogenous protein synthesis is blocked, the intake of some amino acids will be excreted with the urine, affecting its growth. Vitamin B2 should be added to the feed of breeding animals, sows and eggs. Dosage 4-14mg/kg. |
Vitamin B2 naturally exists in animal liver, kidney, meat and dairy foods. Industrial production methods include fermentation and chemical synthesis.
(1) Fermentation. Glucose, corn steep liquor, inorganic salts, etc. were used as the medium, and the special active bacterium Pseudocystis arzinii (Eremothecium ashbyii) was used for submerged fermentation at 28 ℃ for 9 days. The fermentation broth contained 6-8g/L riboflavin products. The extraction yield is 60%-70%.
(2) Chemical synthesis. The better Har synthesis method is to first condensate 3, 4-dimethylaniline and D-ribose at PH = 4 and 28-30 ℃, and then reduce ribosamine by nickel catalytic hydrogenation, and then with aniline Diazonium salt is coupled at 16-26 ℃, then reduced with sodium sulfite (hydrosulfite), and finally synthesized vitamin B2 with barbituric acid (tetraoxazine) ring in acetic acid.